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Keep an eye on Closely (2)pentobarbital will lessen the level or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Potent CYP3A4 inducers may possibly reduce suvorexant efficacy; if elevated suvorexant dose demanded, tend not to exceed 20 mg/daypentobarbital will decrease the extent or outcome of di